List of Medications That Cause Erectile Dysfunction

Medications That Cause Erectile Dysfunction

medications that cause erectile dysfunctionIf you are having difficulty of getting or maintaining an erection, your prescription medications (or recreational drugs) can be the culprit of your limp dick or being impotent. Yes, there are some prescription pills and even over-the-counter medications that cause erectile dysfunction (ED).

Always bear in mind, what causes erectile dysfunction in one man may not affect to another man. So it is highly advisable to talk with your doctor regarding medications you are taking. Your doctor may able rule out any contributing factor to ED and be able to prescribe possible alternative medications for your condition without having a negative effect on your sexual performance.

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Prescription drugs for lowering high blood pressure are among the most common drug-related causes of impotence. Diureticsbeta-blockers and alpha-blockers are the first drugs of choice that a doctor is likely to prescribe if you have a high blood pressure or hypertension. While these drugs may treat your high blood pressure, in the long run they can also affect a man’s sexual performance resulting the risk of ED.

The following is a list of common medications that cause erectile dysfunction or impotence in men.

Antihypertensive Drugs: Diuretics, Beta-blockers, Alpha-Blockers & ACE Inhibitors

  • Diuretics: A common side effect of diuretics is to reduce fluid levels in the body by urination in order to lower down the blood pressure. However, they can sabotage a satisfying sex life by reducing the amount of blood flow to the penis that is necessary for an erection. In other words, the decreased blood flow to the penis can reduce libido and interfere with erections and difficulties with ejaculation. Thiazides are one of the most common cause of male impotence among the high blood pressure medicines. Here are the most common diuretics that cause ED:
    • Chlorothiazide (Diuril)
    • Hydrochlorothiazide (Esidrix, HydroDIURIL, Hydropres, Inderide, Moduretic, Oretic, Lotensin)
    • Indapamide
    • Metolazone (Zaroxolyn)
    • Chlorthalidone
    • Bumetanide
    • Ethacrynic acid (Edecrin)
    • Furosemide (Lasix)
    • Torsemide (Demadex)
    • Amiloride
    • Eplerenone (Inspra)
    • Spironolactone (Aldactone)
    • Triamterene (Dyrenium)

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  • Beta-Blockers: Doctors prescribe beta blockers to lower blood pressure and also lower the risk of heart disease, heart
    attack, and stroke. Common side effects may include dizziness, blurred vision, insomnia (sleep disturbance), loss of libido, depression and impotence – problems getting or maintaining an erection on command. Here are the most common beta-blockers that cause erectile dysfunction:

    • Acebutolol (Sectral)
    • Atenolol (Tenormin)
    • Betaxolol
    • Bisoprolol (Monocor)
    • Carvedilol (Coreg)
    • Metoprolol (Lopressor, Toprol)
    • Nadolol (Corgard)
    • Penbutolol (Levatol)
    • Propranolol (Inderal)
    • Timolol eye drops
  • Alpha-Blockers:
    • Doxasosin Mesylate (Cardura)
    • Parson Hydrochloride (Minipress)
    • Terazosin Hydrochloride (Hytrin)
  • Angiotensin Converting Enzyme (ACE) inhibitors are high blood pressure drugs that help to dilate the blood vessels and to lower blood pressure. Possible effect on sexual function is impotence. Examples of ACE inhibitors include:
    •  Capoten (captopril)
    • Vasotec (enalapril)
    • Prinivil, Zestril (lisinopril)
    • Lotensin (benazepril)
    • Monopril (fosinopril)
    • Altace (ramipril)
    • Accupril (quinapril)
    • Aceon (perindopril)
    • Mavik (trandolapril)
    • Univasc (moexipril)

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  • Estrogen-containing medications
  • Cimetidine (in very high doses)
  • Gonadotropin-releasing hormone agonists
  • Ketoconazole
  • Spironolactone


  • Digoxin
  • Disopyramide

Antihistamine medicines

  • Cimetidine (Tagamet)
  • Dimenhydrinate (Dramamine)
  • Diphenhydramine (Benadryl)
  • Hydroxyzine (Vistaril)
  • Meclizine (Antivert)
  • Nizatidine (Axid)
  • Promethazine (Phenergan)
  • Ranitidine (Zantac)

Chemotherapy drugs

  • Busulifan (Myleran)
  • Cyclophosphamide (Cytoxan)

Muscle relaxants

  • Cyclobenzaprine (Flexeril)
  • Orphenadrine (Norflex)

Non-Steroidal Anti-inflammatory Drugs (NSAID)

  •  Naproxen (Anaprox, Naprelan, Naprosyn)
  • Indomethacin (Indocin)

Painkillers – Opiate analgesics 

  • Codeine
  • Fentanyl (Innovar)
  • Hydromorphone (Dilaudid)
  • Meperidine (Demerol)
  • Methadone
  • Morphine
  • Oxycodone (Oxycontin, Percodan)

Parkinson’s Disease Medications

  • Biperiden (Akineton)
  • Benztropine (Cogentin)
  • Trihexyphenidyl (Artane)
  • Procyclidine (Kemadrin)
  • Bromocriptine (Parlodel)
  • Levodopa (Sinemet)

Prostate Cancer Medications

  • Flutamide (Eulexin)
  • Leuprolide (Lupron)

Psychiatric Medications

  • Antidepressants: 
    •  Amitriptyline
    • Doxepin
  • Antipsychotics: 
    • Phenothiazines
    • Haloperidol
    • Benzisoxazole

Recreational drugs

  • Alcohol
  • Amphetamines
  • Barbiturates
  • Cocaine
  • Marijuana
  • Heroin
  • Nicotine

These list of drugs not only affect and often suppress the central nervous system, but can also cause serious damage to the blood vessels, leading to permanent ED.

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